Regenerative Medicine

Features of HORIE R.P Clinic

Features of HORIE R.P Clinic

Regenerative medicine treatments undergo rigorous scrutiny by the Ministry of Health, Labour and Welfare's designated Regenerative Medicine Certification Committee to ensure their therapeutic validity, safety, physician qualifications, and cell processing systems. HORIE R.P Clinic is a medical institution that has followed the formal process, submitted a Type II Regenerative Medicine Provision Plan to the Ministry of Health, Labour and Welfare, and obtained a plan number.

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Medical Applications Using Stem Cells
'Regenerative Medicine'

The human body possesses the ability to repair damaged or weakened parts. Stem cell-based regenerative medicine amplifies the repair function of stem cells by tens or even millions of times. It targets damaged blood vessels and dysfunctional organs intensively, restoring their function to return the body to its inherent normal state (regeneration). In other words, it is the recovery of bodily functions that you yourself could not achieve through exercise, diet, or rest—recovery achieved by your own “cells.” This is the autologous adipose-derived stem cell therapy performed at our main clinic.

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Cutting-edge medical technology

Autologous adipose-derived stem cell therapy involves culturing these stem cells outside the body to increase their quantity to a certain level before reintroducing them into the patient's own body. Numerous medical research institutions both domestically and internationally are studying its effects and mechanisms. Furthermore, since it is your own stem cells, it is highly safe and has no side effects such as allergies or rejection reactions. This is the most cutting-edge medical technology attracting the most attention right now. Stem cells are found in bone marrow, umbilical cord blood, internal organs, and fat tissue. At our clinic, we harvest abdominal fat, which places minimal burden on the body.

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Collaboration with a Top-Tier
Domestic CPC

For cell culture, essential to regenerative medicine, we collaborate with a Cell Processing Center (CPC). Despite the challenge of culturing adipose-derived stem cells, this CPC is a top-tier domestic cell culture processing facility achieving high standards through its “high survival rate” and “optimal cell size.” Beyond simply increasing stem cell numbers, selecting cells of a size that can move smoothly through blood vessels is also a critical point. The CPC partnered with HORIE R.P Clinic Main Hospital possesses the advanced technical capabilities to perform both these tasks.

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High-Standard Cultivation Technology

Cultivation technology is a crucial point in performing autologous adipose-derived stem cell therapy. Stem cell expansion is performed at the CPC (Cell Processing Center). Administering cultured stem cells is meaningless unless they are viable. Their high survival rate significantly impacts engraftment in the body.

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Diseases Treated with Stem Cell Therapy

01Cerebrovascular disease

Cerebrovascular disorders are diseases caused by blockages or ruptures in the brain's blood vessels, such as stroke (cerebral hemorrhage, cerebral infarction, etc.). Damage to the brain results in various symptoms and aftereffects.

Main Symptoms

■ Initial Symptoms
  • ・Numbness or difficulty moving one side of the body or face
  • ・Slurred speech, inability to speak or understand words
  • ・Partial vision loss, double vision
  • ・Dizziness, unsteadiness, loss of balance
  • ・Severe headache (e.g., subarachnoid hemorrhage)
■ Symptoms During Progression
  • ・Impaired consciousness (slowed response, coma, etc.)
  • ・Difficulty breathing, seizures (in severe cases)
  • ・Worsening hemiplegia or speech impairment
  • ・Urinary or bowel dysfunction
■ Aftereffects (Symptoms that may persist after recovery)
  • ・Motor impairment: Paralysis in limbs, difficulty walking, impaired balance
  • ・Sensory impairment: Numbness, reduced touch sensitivity, pain
  • ・Speech impairment: Slurred speech (dysarthria), inability to speak or understand (aphasia)
  • ・Visual impairment: Visual field defects, double vision (seeing double)
  • ・Memory impairment: Decreased memory, inability to retain new information
  • ・Social behavioral impairment: Inability to control actions or emotions
  • ・Consciousness impairment: Confusion, decreased level of alertness

Related medical conditions

  • Post-spinal cord injury sequelae
  • ・Parkinson's disease
  • ・Alzheimer's dementia
  • ・Cerebral aneurysm

02Osteoarthritis

Osteoarthritis is a condition where joint cartilage wears down due to aging or excessive stress, leading to symptoms such as pain and limited range of motion. It commonly affects weight-bearing joints like the knees and hips and is frequently seen in older adults

Main Symptoms

■ Initial Symptoms
  • ・Pain during movement, joint discomfort
■ Symptoms During Progression
  • ・Pain at rest,
  • ・joint swelling,
  • ・warmth,
  • ・joint deformity,
  • ・restricted range of motion.
  • ・Pain or impairment may occur in the knees, hips, shoulders, hands, elbows, feet, neck, etc.
■ Aftereffects (Symptoms that may persist after recovery)
  • ・Motor impairment: Paralysis in limbs, difficulty walking, impaired balance
  • ・Sensory impairment: Numbness, reduced touch sensitivity, pain
  • ・Speech impairment: Slurred speech (dysarthria), inability to speak or understand (aphasia)
  • ・Visual impairment: Visual field defects, double vision (seeing double)
  • ・Memory impairment: Decreased memory, inability to retain new information
  • ・Social behavioral impairment: Inability to control actions or emotions
  • ・Consciousness impairment: Confusion, decreased level of alertness

Related medical conditions

  • ・Osteoarthritis of the Knee
  • ・Hip Arthritis
  • ・Arthritis
  • ・Meniscus Tear
  • ・Herniated Disc (Cervical/Lumbar)
  • ・Spinal canal stenosis
  • ・Cervical spondylotic myelopathy
  • ・Rheumatism
  • ・Low back pain, headaches, shoulder/neck pain
  • ・Spinal cord injury, ligament injury, tenosynovitis, trigger finger, carpal tunnel syndrome
  • ・Post-fracture pain
  • ・Sports injuries (tennis elbow, baseball shoulder, soccer/golf-related knee/joint injuries, etc.)

03Chronic pain 

Chronic pain refers to pain that persists for three months or longer after an injury or illness has healed. Unlike ordinary pain, it often involves issues with nerves or the brain, and may be classified as “intractable pain,” which is difficult to treat.

Main Types

  • ・Neuropathic Pain
    Pain caused by nerve damage. Characterized by hypersensitive nerves, making it resistant to common pain medications. (Examples: Stroke, spinal cord injury, diabetic neuropathy, cancer-related nerve damage)
  • ・Central Pain
    Pain arising from damage to the brain or spinal cord (central nervous system). May involve feeling pain without a clear cause or experiencing intense pain in paralyzed areas.
  • ・Psychogenic pain
    Pain arising from psychological factors such as stress or anxiety. Prolonged pain can cause the brain to “learn” the pain, leading to persistent pain even without an identifiable cause.

Main Symptoms

■ Initial Symptoms
  • ・Persistent or intermittent pain,
  • ・difficulty pinpointing the location of the pain,
  • ・accompanied by mild numbness or discomfort
■ Symptoms During Progression
  • ・Sleep disturbances,
  • ・loss of appetite,
  • ・taste disorders,
  • ・weight loss,
  • ・autonomic nervous system dysfunction,
  • ・depressed mood,
  • ・drug or alcohol dependence,
  • ・impairment of social functioning, etc.

Related medical conditions

  • ・Arthritis
  • ・Diabetes
  • ・Fibromyalgia
  • ・Post-fracture pain
  • ・Cancer
  • ・Chronic joint pain
  • ・Ligament injury
  • ・Spinal cord injury
  • ・Herniated disc, etc.
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